Monitoring and modulating O-GlcNAcylation: assays and inhibitors of O-GlcNAc processing enzymes
نویسندگان
چکیده
منابع مشابه
Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain
O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins by β-N-acetylglucosamine (GlcNAc). The dynamic addition and removal of O-GlcNAc groups to and from proteins are catalyzed by O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) and β-N-acetylglucosaminidase (O-GlcNAcase, OGA), respectively. O-GlcNAcylation often modulates protein phosphoryl...
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O-linked N-acetylglucosamine modification (O-GlcNAcylation) is a nutrient-dependent protein post-translational modification (PTM), dynamically and reversibly driven by two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) that catalyse the addition and the removal of the O-GlcNAc moieties to/from serine and threonine residues of target proteins respectively. Increasing evidence suggests...
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Swim-training exercise in mice leads to cardiac remodeling associated with an improvement in contractile function. Protein O-linked N-acetylglucosamine (O-GlcNAcylation) is a posttranslational modification of serine and threonine residues capable of altering protein-protein interactions affecting gene transcription, cell signaling pathways, and general cell physiology. Increased levels of prote...
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Hundreds of post-translational modifications (PTM) have been characterized on proteins, including a large variety of glycosylations, among which figures O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as a major PTM that is widespread, being found in viruses, bacteria, and protists through plant and animal cells. In contrast to N and O-glycosylations, O-GlcNAcylation involves ...
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The O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification (O-GlcNAcylation) is the dynamic and reversible attachment of N-acetylglucosamine to serine and threonine residues of nucleocytoplasmic target proteins. It is abundant in metazoa, involving hundreds of proteins linked to a plethora of biological functions with implications in human diseases. The process is catalysed by ...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2021
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2020.12.008